When suggestions are available use up and down arrows to review and ENTER to select. To email a medicine you must sign up and log in. Betahistine (Serc) is a popular medicine that is prescribed to treat a variety of complaints. The concentration of 2-pyridylacetic acid reaches its maximum at 1 hour after intake and declines with half approximately 3.5 hours. Ménière's syndrome is characterised by attach of vertigo, tinnitus, nausea, headache, hearing loss. Not known: hypersensitivity reactions, e.g. Coronavirus: how quickly do COVID-19 symptoms develop and how long do they last? Betahistine is indicated for treatment of Ménière's syndrome, symptoms of which may include vertigo, tinnitus, hearing loss and nausea. If the rash continues or is severe, contact your doctor for advice. To The usual recommended dose of betahistine for adults is 24 mg to 48 mg given in 2 or 3 divided doses (i.e., 12 mg to 24 mg twice a day, or 8 mg to 16 mg three times a day). Teva Betahistine 16mg tablet This medication is typically used for vertigo (dizziness) associated with Meniere's disease. Once your symptoms are under control, your doctor may then reduce your dose to one 8 mg tablet three times a day. My mother is 50 years old and has had vertigo since 8-10 years. The main indication for taking Betahistine is to treat patients with Ménière’s disease, however many patients take Betahistine to relieve other symptoms, such as vertigo, dizziness, and tinnitus. If you have any questions about this medicine ask your pharmacist. those associated with Ménière's disease. There are no proven cases of hazardous interactions. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. Start typing to retrieve search suggestions. White, round, flat, 9.0. mm tablets with bevelled edges with the inscription 'BF' on one side and a breakline on the other side. Maintenance doses are generally in the range 24 - 48 mg daily. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Name of the medicinal product. Betahistine has two modes of action. Vertigo, tinnitus and hearing loss associated with Ménière's syndrome can negatively affect the ability to drive and use machines. If you have ever had an allergic reaction to a medicine. Daily dose should not exceed 48 mg. Pharmacotherapeutic group: antivertigo preparation. Swallow the tablet with a drink of water. The 2-pyridylacetic acid is excreted almost quantitatively in urine within 24 hours after administration. Keep all medicines out of the reach and sight of children. For details see our conditions. Sometimes improvement could be observed only after a couple of weeks of treatment. If you take betahistine every day it is unlikely to stop all attacks, but it may reduce the number and/or the severity of your attacks. White to off-white round (diameter 8.5 mm), uncoated tablets debossed with 'X' and a break line on one side and '88' on the other side. In the dose range between 8 and 48 mg, about 85% of the original dose was recovered in the urine. Never take more than the prescribed dose. 30 szt. If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking. In an 18-month chronic toxicity study in rats with a dose up to 500 mg / kg, there was no evidence of carcinogenic potential. Excipient (s) with known effect: Each tablet contains 100 mg lactose. • hypersensitivity to the active substance(s) or to any of the excipients listed in section 6.1. 100 % [ABPI Medicines Compendium, 2016a; BNF 74, 2017] Not known: Bronchospasms may occur in patients with bronchial asthma (see section 4.4), Not known: cutaneous and subcutaneous hypersensitivity reactions, in particular angioneurotic oedema, urticarial, rash, and pruritus, *Mild gastric complaints (e.g. This is because you may have sudden attacks of a spinning sensation (vertigo) with little warning. You will find the directions for taking the tablets on the label of the pack to remind you about what the doctor said to you. 1 tabletka Betahistine dihydrochloride Accord zawiera 8 mg, 16 mg lub 24 mg dichlorowodorku betahistyny. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms, e.g. Max: 48 mg daily. Take betahistine exactly as your doctor tells you to. Qualitative and quantitative composition. If you buy any medicines, check with a pharmacist that they are suitable to take with betahistine. Patient does not provide medical advice, diagnosis or treatment. Read more about the prescription drug BETAHISTINE - ORAL. It will give you more information about betahistine, and will also provide you with a full list of the side-effects which you could experience from taking it. For these reasons, before you start taking betahistine it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. To There is a case report of an interaction with ethanol and a compound containing pyrimethamine with dapsone and another of potentiation of betahistine with salbutamol. Betahistine dihydrochloride tabletki 16 mg - Lek Betahistine ma postać tabletek. Betahistine 16 mg Tablets - Taj Dearob Pharma | Betahistine dihydrochloride (Beeta-hist-een dye-hi-droh-clor-ride) is a medicine which is used in Ménière's syndrome. Children Betahistine Tablets are not recommended for use in children below 18 years.. If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice. 100 % 22,17 PLN 22,17 PLN Betahistine dihydrochloride: Polvertic tabl. Each tablet contains Betahistine dihydrochloride 16mg. This information is intended for use by health professionals, Betahistine dihydrochloride 16 mg tablets, Each tablet contains 100 mg lactose monohydrate. 6.7 Physicochemical Properties. Never give it to other people even if their condition appears to be the same as yours. tabl. Thông tin thuốc Betahistin 16 A.T - Viên nén, SDK: VD-24741-16, giá Thuốc Betahistin 16 A.T, Công dụng, chỉ định, liều dùng Betahistin 16 A.T , Nhà Sản xuất: Công ty Cổ phần Dược phẩm An Thiên - VIỆT NAM - Thuocbietduoc.com.vn Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Studies on chronic oral toxicity over a period of 18 months in rats with a dose of 500 mg / kg and for 6 months in dogs with a dose of 25 mg / kg indicate that betahistine is well tolerated without definitive toxicity. 2. Although an antagonism between Betahistine and antihistamines could be expected on a theoretical basis, no such interactions have been reported. Betahistine dihydrochloride is a white to almost white crystalline powder, which is very hygroscopic. Betahistine increases histamine turnover and release by blocking presynaptic H3-receptors and inducing H3-receptor downregulation. Tabletki 24 mg zawierają laktozę - jeśli stwierdzono wcześniej u pacjenta nietolerancję niektórych cukrów, należy skontaktować się z lekarzem przed przyjęciem leku After oral administration of betahistine, its plasma levels are very low. Lek zawiera laktozę - jeśli stwierdzono wcześniej u pacjenta nietolerancję niektórych cukrów, należy skontaktować się z lekarzem przed przyjęciem leku. anaphylaxis. Betahistine is contraindicated in patients with phaeochromocytoma. British National Formulary, 77th Edition (Mar 2019); British Medical Association and Royal Pharmaceutical Society of Great Britain, London. Animal studies show no influence on fertility in rats. Pharmacodynamics In ten healthy male volunteers, single oral doses of 8, 16, and 32 mg of betahistine (24 mg) - 60 szt. Zobacz opis i cenę produktu, skorzystaj z dostępnych rabatów i niskich cen apteki online! Some people with Ménière's disease claim their symptoms improve with a low-salt diet, regular exercise, stopping smoking, and cutting out caffeine and alcohol. Product Name Vergo 16, 16 mg, tablet. 8-16 mg 3 times a day. Mutagenic and carcinogenic potential Betahistine has no mutagenic potential. Sometimes improvement could be observed only after a couple of weeks of treatment. However betahistine is subject to metabolism in the liver. Upgrade to Patient Pro Medical Professional? If you forget to take a dose, do not worry, just remember to take the next dose when it is due. Betahistine is a medicine called a histamine analogue. Ménière's disease is a condition of the inner ear. How to cope with side effects. 2. All rights reserved. Betahistine 16 mg tablets. Betahistine Dihydrochloride 16mg Tablets. Betahistine Mylan (betahistine dihydrochloride) 16 mg tablets: round, biconvex, scored, white to almost white uncoated … Betahistine dihydrochloride is thought to work by ... Betahistine dihydrochloride Accord Betahistine dihydrochloride Accord jest lekiem wskazanym w leczeniu objawów zespołu Ménière’a, takich jak: zawroty głowy, „dzwonienie” w uszach, utrata słuchu i nudności. Maintenance doses are generally in the range 24 – 48 mg daily. Active ingredient: Betahistine dihydrochloride 16 mg. Excipients: Copovidone 10.4 mg, lactose monohydrate (milk sugar) 83.2 mg, magnesium stearate 2.0 mg, microcrystalline cellulose 128.4 mg. Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. Mechanism of action. During reproductive toxicity studies, effects were only seen at exposures considered to be well above the maximum human exposure, indicating minimal relevance during clinical use. Each tablet contains 16 mg Betahistine dihydrochloride . Some patients experienced mild to moderate symptoms with doses up to 640 mg (e.g. Whilst histamine has positive inotropic effects on the heart, betahistine is not known to increase cardiac output and its vasodilator effect may produce a small fall in blood pressure in some patients. View Price. 5.1 Pharmacodynamic Properties. Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. The efficacy of betahistine may be due to its ability to modify the circulation of the inner ear or due to a direct effect on neurons of the vestibular nucleus. Become a COVID-19 treatment pioneer today. 1. For the full list of excipients, see Section 6.1 List of Excipients. Tabletki 24 mg można podzielić na dwie równe dawki. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. (8 mg) - 30 szt. Where possible, take the tablets with something to eat. from the best health experts in the business. Betahistine tablets are not recommended for use in children and adolescents below age 18 due to lack of data on safety and efficacy. The attacks can vary in severity, and in how often they occur. Betahistine 16mg Tablets are imprinted with ‘B16’ on one side. Tabletkę 16 mg można podzielić na dwie równe części. Do not keep out-of-date or unwanted medicines. Any unused product or waste material should be disposed of in accordance with local requirements. Reporting suspected adverse reactions after authorisation of the medicinal product is important. There are insufficient data on the use of betahistine in pregnant women. The tablets are packed in blister strips. It works by improving the blood flow in the inner ear which reduces the pressure of excess fluid there. Little or no binding occurs with human plasma proteins. Try our Symptom Checker Got any other symptoms? เบตาฮีสทีน (betahistine) เป็นยาในกลุ่มยาบรรเทาอาการวิงเวียนศีรษะ (antivertigo) ยาสำหรับรับประทาน ยาเม็ด ประกอบด้วยเบตาฮีสทีน ขนาด 6 12 16 และ 24 มิลลิกรัม APO-Betahistine 16 mg Tablets . 16 mg tablets. Are the new COVID-19 swab tests accurate? Pharmaceutical form. Betahistine jest lekiem stosowanym w leczeniu objawów choroby Méni?re'a, takich jak zawroty głowy, dzwonienie w uszach, utrata słuchu i nudności. Each tablet contains 16 mg of betahistine dihydrochloride. More serious complications (convulsion, pulmonary or cardiac complications) were observed in cases of intentional overdose of betahistine especially in combination with other overdosed drugs. Caution is advised in patients with severe hypotension. Dosage can be adjusted to suit individual patient needs. Adverse reactions affecting the central nervous system were seen in dogs and baboons after intravenous doses of 120 mg / kg and higher. Take the container with you, even if it is empty. 2. Although there is little evidence to prove that diet and lifestyle can help, these may be worth trying. Excipient(s) with known effect: lactose monohydrate. 30 szt. COVID-19: how to treat coronavirus at home. The usual recommended dose of betahistine for adults is 24 mg to 48 mg given in 2 or 3 divided doses (i.e., 12 mg to 24 mg twice a day, or 8 mg to 16 mg three times a day). Its effects can be noticed within a few hours. Elimination of betahistine takes place mainly by metabolism and the metabolites are subsequently eliminated mainly by renal excretion. The main indication for taking Betahistine is to treat patients with Ménière’s disease, however many patients take Betahistine to relieve other symptoms, such as vertigo, dizziness, and tinnitus. It is thought that a build-up of fluid in the inner ear causes the symptoms. Lek Betahistine Polfarmex poprawia przepływ krwi w uchu wewnętrznym. Date of first authorisation/renewal of the authorisation. What you need to know about post-viral fatigue. Betahistine (Serc) is a popular medicine that is prescribed to treat a variety of complaints. Linia podziału na tabletce tylko ułatwia rozkruszenie w celu ułatwienia połkni ę cia, a nie podział na równe dawki. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme. Betahistine dihydrochloride Accord (tabletki) Betahistyna Bluefish (tabletki) Betanil forte (tabletki) Betaserc ODT (tabletki ulegające rozpadowi w jamie ustnej) Histigen (tabletki) Lavistina (tabletki) Polvertic (tabletki) Verhist (tabletki) Vertix 8 mg (tabletki) Vertix 16 mg (tabletki) Vertix 24 mg (tabletki) Betahistine dihydrochloride. Clinical intolerance to Betahistine may occur in bronchial asthma patients (see section 4.5 and 4.8) - These patients should therefore be monitored carefully during the treatment with betahistine. It typically causes attacks of dizziness with a spinning sensation (vertigo), hearing loss and noises in the ear (tinnitus). Betahistine is regarded to have no or negligible effects on the ability to drive and use machines as no effects potentially influencing this ability were found to be related to betahistine in clinical studies. On this page about Betahistine (AS) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. The active ingredient is a specific histamine agonist with virtually no H2-activity. Patient is a UK registered trade mark. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for BETAHISTINE DIHYDROCHLORIDE. The usual dose after this is 24-48 mg daily (as three divided doses). As betahistine mesilate: 6-12 mg tid. “The following undesirable effects have been experienced with the below indicated frequencies in betahistine-treated patients in placebo-controlled clinical trials and in post-marketing reports: very common ( 1/10); common ( 1/100 to <1/10); uncommon ( 1/1,000 to <1/100); rare ( 1/10,000 to <1/1,000); very rare (<1/10,000); and not known (frequency cannot be estimated from the available data). Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Instructions This medication is typically used 3 times a day. private prescription price learn more . The usual starting dose is one to two 8 mg tablets or a half to one 16 mg tablet three times a day. Prescribe betahistine 16 mg orally three times daily (preferably with food). Betahistine dihydrochloride: 9.20 zł 2020-02-14 Betahistyna Bluefish tabl. This explains the efficacy of betahistine in the treatment of vertigo. To prevent stomach upset, it is recommended that this medication be taken with food. For the full list of excipients, see section 6.1. Betahistine is a histamine analogue, concurrent administration of H1 antagonists may cause a mutual attenuation of effect of the active agents. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Betahistine dihydrochloride Accord zawiera laktozę Lek zawiera 50 mg laktozy jednowodnej w tabletkach o mocy 8 mg i 100 mg laktozy jednowodnej w tabletkach o mocy 16 mg. Leku nie należy stosować u pacjentów z rzadko występującą dziedziczną nietolerancją galaktozy, niedoborem laktazy (typu Lapp) lub z zespołem złego wchłaniania Coronavirus: what are moderate, severe and critical COVID-19? The name of your medicine is Betahistine Dihydrochloride 8mg or 16mg Tablets. There is no data available for patients with renal impairment. Dated June 2016. The tablet can be divide into two equal halves. Instructions This medication is typically used 3 times a day. Before you buy betahistine, compare prices at U.S., Canadian, and international online pharmacies. (16 mg) - 30 szt. Each tablet contains 8mg, 16mg, 24mg, 32 mg betahistine dihydrochloride. nausea, somnolence, abdominal pain).Other symptoms of betahistine overdose are vomiting, dyspepsia, ataxia and seizures. Take them to your local pharmacy which will dispose of them for you. Following the absorption, the drug is metabolized rapidly in the metabolite and almost completely in metabolite 2-pyridylacetic acid. Adult: For vertigo, tinnitus and hearing loss associated in patients with Meniere’s disease: As betahistine dihydrochloride: Initially, 8-16 mg tid or 24 mg bid, adjusted according to individual response.Maintenance: 24-48 mg daily. private prescription price learn more . As betahistine is a synthetic analogue of histamine it may induce the release of catecholamines from the tumor resulting in severe hypertension. Its effects can be noticed within a few hours. Excess fluid can send signals to the brain causing nausea, dizziness or spinning sensations (symptoms of Ménière's disease). Betahistine dihydrochloride Accord zawiera laktozę Lek zawiera 50 mg laktozy jednowodnej w tabletkach o mocy 8 mg i 100 mg laktozy jednowodnej w tabletkach o mocy 16 mg. Leku nie należy stosować u pacjentów z rzadko występującą dziedziczną nietolerancją galaktozy, niedoborem laktazy (typu Lapp) lub z zespołem złego wchłaniania If you are a driver, you must stop driving when Ménière's disease is diagnosed. Betahistine hydrochloride works by altering the levels of histamine-1 and histamine-3 in the body, which can help dilate blood vessels in the brain that mediate some of the symptoms of Meniere's syndrome. COVID-19 coronavirus: what is an underlying health condition? Maintenance dose is usually 24–48 mg daily. The tablet can be divided into equal doses. There is limited data in the elderly, betahistine should be used with caution in this population. Ce document intitulé « BETAHISTINE - Indications, posologie et effets secondaires » issu de Journal des Femmes (sante-medecine.journaldesfemmes.fr) est soumis au droit d'auteur. If it does, it can then be continued. The usual dose is: Adults. Betahistine 16 mg Tablets - Taj Dearob Pharma | Betahistine dihydrochloride (Beeta-hist-een dye-hi-droh-clor-ride) is a medicine which is used in Ménière's syndrome. How to treat constipation and hard-to-pass stools. 85-90% of the radioactivity of an 8 mg dose appears in the urine over 56 hours, with maximum excretion rates reached within 2 hours of administration. (see section 5.3). It appears to act on the precapillary sphincter in the stria vascularis of the inner ear, thus reducing the pressure in the endolymphatic space. The table below contains some of the most common ones associated with betahistine. Important information about all medicines. 5 Pharmacological Properties. Adults: Initial oral treatment is 8 to 16 mg three times daily, taken preferably with meals. Betahistine is rapidly and completely absorbed after oral administration of the drug in tablets, and peak plasma concentrations of 14C-labelled betahistine are attained after approximately one hour of oral administration for fasting subjects. It is not known whether betahistine is excreted in breast milk in humans. Pharmaceutical form. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Serc 16 mg tablets are available in packs of 10 and 25 tablets. What Betahistine looks like and the contents of the pack Tablet. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. For a full list of excipients, see section 6.1. Take betahistine exactly as your doctor tells you to. No unchanged betahistine has been detected in urine. On this page about Betahistine (Apo) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. Based on in-vitro data, no in-vivo inhibition on Cytochrome P450 enzymes is expected. The potential risk for humans is unknown. betahistine sandoz 16mg tablets 25. drug name: betahistine product id: 2675754. select a prescription. The increased amounts of histamine released from histaminergic nerve endings stimulates H1 receptors, thus augmenting the direct agonistic effects of betahistine on these receptors. In addition, betahistine has a powerful antagonistic effects at H3 receptors, and increases the levels of neurotransmitters released from the nerve endings. Each tablet contains 8mg, 16mg, 24mg, 32 mg betahistine dihydrochloride. On this page about Betahistine (AS) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. Coronavirus: what are asymptomatic and mild COVID-19? בטאהיסטין טבע ® 16 מ"ג . This reduces the amount of fluid in the inner ear and prevents symptoms from developing. Betahistine dihydrochloride is a type of medicine called a histamine analogue. selegiline). This site uses cookies. [ABPI Medicines Compendium, 2016a; BNF 74, 2017] Maintenance dose is usually 24–48 mg daily. Caution is advised in the treatment of patients with peptic ulcer or a history of peptic ulceration, because of the occasional dyspepsia encountered in patients on betahistine. Lek Betahistine 1 Polfarmex zawiera 8 mg lub 16 mg lub 24 mg substancji czynnej - dichlorowodorku betahistyny, który jest analogiem histaminy 2 (neuroprzekaźnika występującego w organizmie ludzkim). The lowest price for Betahistine (serc) 16 mg is $0.31 per tab for 300 tabs at PharmacyChecker-accredited online pharmacies. Manufacturer's PIL, Serc® 8 mg and 16 mg tablets; Mylan Products Limited, The electronic Medicines Compendium. As a precautionary measure, it is preferable to avoid the use of Betahistine during pregnancy. Daily dose should not exceed 48 mg. Usage: Betahistine is orally administered. Continue, 2. Prescribe betahistine 16 mg orally three times daily (preferably with food). Primarily, it has a direct stimulating (agonistic) effect on H1 receptors located on blood vessels in the inner ear. Balanse (16mg) Cadila Pharmaceuticals Ltd. (LE Sante) Tablet. Consumer information about the medication BETAHISTINE - ORAL , includes side effects, drug interactions, recommended dosages, and storage information. For the full list of excipients, see section 6.1. Betahistine dihydrochloride Accord tabl. This explains the potent vasodilatory effects of betahistine in the inner ear. To bookmark a medicine you must sign up and log in. Betahistine is excreted in rat milk. What to do about: feeling sick - take betahistine with or after a meal … The effects post-partum seen in animal studies were limited to very high doses. Betahistine dihydrochloride tablets are not recommended for use in children and adolescents below 18 years of ages, as there are no data on efficacity and safety in these age groups. The information on this page is written and peer reviewed by qualified clinicians. To view the changes to a medicine you must sign up and log in. Ingredients Serc contains 16 mg of betahistine dihydrochloride as the active ingredient: It also contains. Each tablet contains 24 mg betahistine dihydrochloride.-The other ingredients are microcrystalline cellulose, mannitol, povidone, crospovidone, citric acid anhydrous, colloidal anhydrous silica, talc and stearic acid. Caution is advised in prescribing betahistine to patients with either urticaria, rashes or allergic rhinitis, because of the possibility of aggravating these symptoms. Where possible, take betahistine tablets with something to eat, such as a snack or straight after a meal. She has dizziness on sudden movements especially on looking down and sideways for 2 weeks. Do not take two doses together to make up for a forgotten dose. (Betahistine Dihydrochloride) 8 mg, 16 mg, and 24 mg tablets THERAPEUTIC CLASSIFICATION Anti-vertigo Agent CLINICAL PHARMACOLOGY Betahistine is a histamine H 1-agonist with an intrinsic activity e qual to that of histamine and an H 1-agonistic activity of about 0.07 times that of histamine. Betahistine diHCl Apotex 16 mg not available RVG 23267 APOTEX EUROPE B.V. NL . (16 mg) - 30 szt. The usual recommended dose of betahistine for adults is 24 mg to 48 mg given in 2 or 3 divided doses (i.e., 12 mg to 24 mg twice a day, or 8 mg to 16 mg three times a day). The usual adult starting dose is 8 to 16 mg (half to one tablet) taken three times a day. It is usual to take one 16 mg tablet three times a day at first. Betahistine dihydrochloride Accord 16 mg, tabletki. Toute reproduction ou représentation totale ou partielle de ce site par quelque procédé que ce … DOSAGE Orally, whilst eating. It is usual to take one 16 mg tablet three times a day at first. It is used as a treatment for Ménière’s syndrome, a condition caused by the pressure of excess fluid in the inner ear. tabl. 100 % 16,84 PLN 16,84 PLN Betahistine dihydrochloride: Polvertic tabl. Our clinical information is certified to meet NHS England's Information Standard.Read more. Once your symptoms are under control, your doctor may then reduce your dose to one 8 mg tablet three times a day. Taken together these properties contribute to its therapeutic benefits in Ménière's syndrome.
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betahistine 16 mg 2021